A型肉毒毒素治疗Meige综合征的方法及效果分析(1)
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[摘要]目的：探讨A型肉毒毒素治疗Meige综合征的方法及疗效。方法：47例患者在肌电图引导下用兼作注射器的针电极进行，在患者肌痉挛部位用A型肉毒毒素肌肉内注射，每点注射量为0.1～0.2ml(含肉毒毒素 2.5～5 U)，注射点数为数点～8点。根据 Cohen、Albert痉挛强度分级评估疗效。结果：注射后一般 3～4天起效，疗效持续 3～6个月，复发者重复注射仍有效。治疗后患者肌痉挛强度明显下降，与治疗前比较有极显著性差异(P<0.01)；症状完全缓解和明显缓解者达 89.4%，治疗前后疗效比较有极显著性差异(P<0.01)。不良反应主要有：局部水肿、咬肌无力、眼睑下垂等，一般两周内均能恢复。结论：局部注射A型肉毒毒素治疗Meige综合征为一种安全有效、简便易行的治疗手段。
[关键词]A型肉毒毒素；Meige综合征；效果
[中图分类号]R622[文献标识码]A[文章编号]1008-6455(2011)02-0191-03
Botulinum toxin type A treatment of Meige syndrome of the method and result analysis
WANG Jian1, GAO Ping-feng2,ZHOU Fa-ming1, XI Gang-ming1﹟
(1. Department of Neurology, Affiliated People's Hospital of Hubei Medical College,Shiyan 442000, Hubei,China;2.Department of Internal Medicine,Shennongjia Hospital of Chinese Medicine，Shennongjia 442422，Hubei,China)
Abstract:ObjectiveDiscusses botulinum toxin type A treatment of Meige syndrome the method and the effect.Methods47 patients under the guidance of the EMG needle electrode with a double as the syringe,Spasm sites in patients with botulinum toxin type A intramuscular injection,each injected volume 0.1～0.2ml (including botulinum toxin 2.5～5U),number of injection points to 8 points points. According to Cohen,Albert spasm intensity grading evaluation curative effect.ResultsAfter the injection,the general 3～4days of effect,the curative effect continued for 3～6 months,the recrudescence duplicate injection was still effective,After the treatment,the patient myospasm intensity obvious drop, the comparison has the extremely significance difference before the treatment (P<0.01).The symptom alleviates and the obvious alleviation completely reaches 89.4%,around the treatment the curative effect comparison has the extremely significance difference (P<0.01). Adverse reactions are mainly: local edema,bite muscle weakness,ptosis and so on, generally all can recover within two weeks.ConclusionsLocal injection of botulinum toxin type A treatment of Meige syndrome is a safe and effective and feasible treatment.
Key words:Botulinum Toxin Type A;Meige syndrome;effect
Meige综合征又称眼睑痉挛、口下颌肌张力障碍综合征 ......
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