胺碘酮对急性心肌梗死溶栓术后SOD\MDA的影响(2)
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本试验应用AM对AMI溶栓前干预,结果降低血清MDA含量及增加血清SOD活性,说明AM对心肌I/RI有抗氧化保护作用。由于临床患者过少,且仅用MDA含量及SOD活性反映AM对心肌I/RI有抗氧化保护作用,故本试验有一定的局限性,但在AM临床应用上有一定的指导意义。
[参考文献]
[1]中华医学会心血管病学分会.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志, 2001, 29 (12):710.
[2]Lapenna D,Ciofani G,Pierdomenico SD,et al. Amiodarone inhibits tocopherol-mediated human lipoprotein peroxidation[J].Biochemical Pharmacology,2007,74(2):265-272.
[3]Halici Z,Dengiz GO,Odabasoglu F, et al.Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema[J].European Journal of Pharmacology,2007,566(1/3):215-221.
[4]Hiroyuki T, Masafumi K, Tomohiro A,et al.Targeting of ischemic/reperfused myocardium by liposomal amiodarone reduced ventricular fibillilation in rats[J].Circulation,2009,120: S631.
[5]Celestino D,Medei E,Moro S,et al.Acute in vitro effects of dronedarone,an iodine-free derivative,and amiodarone,on the rabbit sinoatrial node automaticity: a comparative study[J]. Journal of Cardiovascular Pharmacology and Therapeutics,2007,12(3):248-257.
[6] Yuehui Y,Darshan D,Zengchang L,et al.Prospective randomized study comparing amiodarone vs ......
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